IgA

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Model of human Iga1 [[1iga]]

Links

IgA

  • Fab and Fc Fragments
Refined crystal structure of the galactan-binding immunoglobulin fab j539 at 1.95-angstroms resolution 2fbj
Phosphocholine binding immunoglobulin fab mc/pc603. an x-ray diffraction study at 2.7 angstroms 1mcp
Phosphocholine binding immunoglobulin fab mc/pc603. an x-ray diffraction study at 3.1 angstroms 2mcp
Crystal structure of human FcaRI bound to IgA1-Fc 1ow0
Refined crystal structure of a recombinant immunoglobulin domain and a complementarity-determining region 1-grafted mutant 2imm and2imn
Crystal structure of a Staphylococcus aureus protein (SSL7) in complex with Fc of human IgA1 2qej
  • Monomeric
Model of human IgA1 determined by solution scattering, curve-fitting, and homology modeling 1iga
Model of human IgA2 determined by solution scattering, curve fitting and homology modelling 1r70
  • Dimeric and Secretory
Solution structure of human dimeric immunoglobulin A 2qtj
Solution structure of human secretory IgA1 3chn
Solution Structure of Human SIgA2 3cm9
Solution structure of human secretory component 2ocw

Related Molecules

  • non-IgA antibody isotypes
IgM: Solution structure of human Immunoglobulin M 2rcj
IgG: Crystal structure of the intact human IgG B12 with broad and potent activity against primary HIV-1 isolates: a template for HIV vaccine design 1hzh
IgG: Three=dimensional structure of a human immunoglobulin with a hinge deletion 1mco
IgD: Semi-extended solution structure of human myeloma immunoglobulin D determined by constrained X-ray scattering 1zvo
IgE: Structure of the human ige-fc bound to its high affinity receptor fc(epsilon)ri(alpha) 1f6a
  • Other C-type immunoglobulin examples
MHC: Crystal Structure of monomeric human beta-2-microglobulin 1lds
TCR: Crystal Structure of the G17E/A52V/S54N/Q72H/E80V/L81S/T87S/G96V variant of the murine T cell receptor V beta 8.2 domain 2apv
  • V-type immunoglobulin examples
Crystal Structure of a Ligand-Binding Domain of the Human Polymeric Ig Receptor, pIgR 1xed
Crystal structure of human FcaRI 1ovz
Influenza virus hemagglutinin complexed with a neutralizing antibody 1qfu

References

  1. 1.0 1.1 1.2 1.3 1.4 Bonner A, Perrier C, Corthesy B, Perkins SJ. Solution structure of human secretory component and implications for biological function. J Biol Chem. 2007 Jun 8;282(23):16969-80. Epub 2007 Apr 11. PMID:17428798 doi:http://dx.doi.org/10.1074/jbc.M701281200
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Furtado PB, Whitty PW, Robertson A, Eaton JT, Almogren A, Kerr MA, Woof JM, Perkins SJ. Solution structure determination of monomeric human IgA2 by X-ray and neutron scattering, analytical ultracentrifugation and constrained modelling: a comparison with monomeric human IgA1. J Mol Biol. 2004 May 14;338(5):921-41. PMID:15111057 doi:http://dx.doi.org/10.1016/j.jmb.2004.03.007
  3. 3.0 3.1 3.2 3.3 3.4 Bonner A, Almogren A, Furtado PB, Kerr MA, Perkins SJ. Location of secretory component on the Fc edge of dimeric IgA1 reveals insight into the role of secretory IgA1 in mucosal immunity. Mucosal Immunol. 2009 Jan;2(1):74-84. Epub 2008 Oct 8. PMID:19079336 doi:http://dx.doi.org/10.1038/mi.2008.68
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 Boehm MK, Woof JM, Kerr MA, Perkins SJ. The Fab and Fc fragments of IgA1 exhibit a different arrangement from that in IgG: a study by X-ray and neutron solution scattering and homology modelling. J Mol Biol. 1999 Mar 12;286(5):1421-47. PMID:10064707 doi:http://dx.doi.org/10.1006/jmbi.1998.2556
  5. 5.0 5.1 5.2 5.3 Bonner A, Almogren A, Furtado PB, Kerr MA, Perkins SJ. The nonplanar secretory IgA2 and near planar secretory IgA1 solution structures rationalize their different mucosal immune responses. J Biol Chem. 2009 Feb 20;284(8):5077-87. Epub 2008 Dec 23. PMID:19109255 doi:http://dx.doi.org/10.1074/jbc.M807529200
  6. 6.0 6.1 6.2 6.3 Attwood, T. "Immunoglobulin superfamily " ImPrints Retrieved April, 2009, from http://www.jenner.ac.uk/Bioinformatics/ImPRINTS/immunoglobulin_superfamily_background.htm.
  7. (nov 22 2007). "Superfamily: immunoglobulin." SCOP, from http://scop.mrc-lmb.cam.ac.uk/scop/data/scop.b.c.b.b.html.
  8. 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 Bonner A, Furtado PB, Almogren A, Kerr MA, Perkins SJ. Implications of the near-planar solution structure of human myeloma dimeric IgA1 for mucosal immunity and IgA nephropathy. J Immunol. 2008 Jan 15;180(2):1008-18. PMID:18178841
  9. 9.0 9.1 Herr AB, Ballister ER, Bjorkman PJ. Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc. Nature. 2003 Jun 5;423(6940):614-20. Epub 2003 May 21. PMID:12768205 doi:http://dx.doi.org/10.1038/nature01685
  10. Falk, R. "IgA Nephropathy." UNC Kidney Center, from http://www.unckidneycenter.org/kidneyhealthlibrary/iganephropathy.html.


--Rebecca Martin 01:23, 2 May 2009 (IDT)

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