Function
Gramicidin (GCDN) is a polypeptide composed of alternating L- and D-amino acids. It is produced by the bacteria Bacillus brevis[1].
- GCDN S is an antibiotic cyclic polypeptide.
- GCDN D is a mixture of GCDN A, B, C.
See theoretical model of Gramicidin Channel in Lipid Bilayer and Gramicidin Channel in Lipid Bilayer (Spanish).
Relevance
GCDN has bactericidal activity and is used as a topical antibiotic and as topical contraceptive[2].
Structural highlights: Gramicidin A
Protein:
, chain A in green, chain B in salmon.
Non-standard residues:
Ligands:
, C atom of methanol in cyan.
, C atom of thiocyanate in magenta.
(in purple).
