|Yeast Gal4 complex with DNA and Zn+2 ions 1d66|
Gal3-Gal80-Gal4 proteins of yeast comprise a signal transducer that controls the galactose-inducible Gal4-mediated transcription activation of GAL regulon genes. Gal3 and Gal4 are regulators of the rapid induction of the galactose system. In the absence of galactose Gal80 binds to Gal4 and prohibits it from activating transcription. In the presence of galactose, Gal3 binds to Gal80 to prohibit its inhibition of Gal4. For Gal4 details see
User: Wayne Decatur/Gal 4
The Gal4 protein consists of a of identical subunits.
3D Structures of Gal3-Gal80-Gal4
Updated on 03-March-2016
- ↑ Traven A, Jelicic B, Sopta M. Yeast Gal4: a transcriptional paradigm revisited. EMBO Rep. 2006 May;7(5):496-9. PMID:16670683 doi:http://dx.doi.org/10.1038/sj.embor.7400679
- ↑ Pilauri V, Bewley M, Diep C, Hopper J. Gal80 dimerization and the yeast GAL gene switch. Genetics. 2005 Apr;169(4):1903-14. Epub 2005 Feb 3. PMID:15695361 doi:http://dx.doi.org/10.1534/genetics.104.036723