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Yeast Gal4 complex with DNA and Zn+2 ions 1d66
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Gal3-Gal80-Gal4 proteins of yeast comprise a signal transducer that controls the galactose-inducible Gal4-mediated transcription activation of GAL regulon genes. Gal3 and Gal4[1] are regulators of the rapid induction of the galactose system. In the absence of galactose Gal80[2] binds to Gal4 and prohibits it from activating transcription. In the presence of galactose, Gal3 binds to Gal80 to prohibit its inhibition of Gal4. For Gal4 details see
User:Amir Mitchell/Gal4
User: Wayne Decatur/Gal 4
Evans Gal4
DNA-protein interactions.

The Gal4 protein consists of a of identical subunits.

3D Structures of Gal3-Gal80-Gal4

Updated on 03-March-2016


  1. Traven A, Jelicic B, Sopta M. Yeast Gal4: a transcriptional paradigm revisited. EMBO Rep. 2006 May;7(5):496-9. PMID:16670683 doi:
  2. Pilauri V, Bewley M, Diep C, Hopper J. Gal80 dimerization and the yeast GAL gene switch. Genetics. 2005 Apr;169(4):1903-14. Epub 2005 Feb 3. PMID:15695361 doi:

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Michal Harel, Ann Taylor, Wayne Decatur, Jaime Prilusky

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