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From Proteopedia

Focal adhesion kinase 1 kinase domain complex with pyrimidine derivative inhibitor and sulfate, 2jkk
Ligands:	,
Activity:	Non-specific protein-tyrosine kinase, with EC number 2.7.10.2
Related:	1ktm, 2j0k, 2j0m, 2j0j, 2al6, 1qvx, 1pv3, 2j0l, 2aeh, 2jkm, 2jko, 2jkq
Structural annotation: Resources: InterPro : Ipr000299, Ipr000719, Ipr001245, Ipr005189, Ipr008266, Ipr011009, Ipr017441 Pfam : PF07714 UniProt : Q00944
Functional annotation: Cellular component: cell junction cytoskeleton plasma membrane focal adhesion membrane Biological process: signal complex assembly protein amino acid phosphorylation Molecular function: non-membrane spanning protein tyrosine kinase activity signal transducer activity kinase activity transferase activity protein tyrosine kinase activity nucleotide binding ATP binding protein kinase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

For details on focal adhesion kinase see Molecular Playground/FAK.

3D Structures of focal adhesion kinase

Updated on 07-March-2013

Focal adhesion kinase 1 (FAK1)

FAK1 targeting domain

1k04, 1k05 – hFAK1 targeting domain – human
1ow6, 1ow7 - hFAK1 targeting domain + paxillin LD4 motif
1ow8 - hFAK1 targeting domain + paxillin LD2 motif
3b71 - hFAK1 targeting domain + ADP + ATP
1ktm, 1qvx, 1pv3 - cFAK1 targeting domain – chicken – NMR

FAK1 kinase domain

1mp8 - hFAK1 kinase domain
2etm, 3bz3 - hFAK1 kinase domain + pyrimidine derivative
2ijm - hFAK1 kinase domain + ADP + ATP
2j0l - cFAK1 kinase domain phosphorylated
2jkk, 2jkm, 2jko, 2jkq - cFAK1 kinase domain + pyrimidine derivative

FAK1 FERM domain

2j0j, 2j0k, 2j0m - cFAK1 kinase + FERM domains
2aeh, 2al6 - cFAK1 FERM domain

Focal adhesion kinase 2 (FAK2)

3cc6, 3fzo – hFAK2 kinase domain
3fzp - hFAK2 kinase domain + ATPγS
3fzr, 3fzt, 3h3c, 3et7 – hFAK2 kinase domain + pyrimidine derivative
3fzs – hFAK2 kinase domain + naphthaline derivative