Ephrin

Function

Ephrins (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation ^[1]. See also Ephrin receptor, Eph/ephrin signaling pathway, Ephrin Type-A Receptor.

Disease

Eph-A5 is implicated in spinal cord injury. Eph-A1 is implicated in myocardial injury and renal reperfusion injury.

Structural highlights

(PDB code 3mx0).^[2]