Deoxyuridine 5'-triphosphate nucleotidohydrolase

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dUTPase trimer complex with dUTP, nitrate and Tris buffer 1smc
Ligands: , ,
Gene: DUT, RV2697C, MT2771, MTCY05A6.18C, MB2716C (Mycobacterium tuberculosis)
Activity: dUTP diphosphatase, with EC number 3.6.1.23
Related: 1mq7, 1six, 1sjn, 1slh, 1sm8
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Deoxyuridine 5’-triphosphate nucleotidohydrolase (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. DUTP inhibitors are being tested as possible anti-bacterial agents targeting diseases like malaria, leishmaniasis, tuberculosis and trypanosomiasis. Prokaryotic DUTP contains metal ion.

3D structures of dUTPase

Updated on 23-November-2014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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