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Deoxyuridine 5'-triphosphate nucleotidohydrolase

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dUTPase trimer complex with dUTP, nitrate and Tris buffer 1smc
Ligands: , ,
Gene: DUT, RV2697C, MT2771, MTCY05A6.18C, MB2716C (Mycobacterium tuberculosis)
Activity: dUTP diphosphatase, with EC number 3.6.1.23
Related: 1mq7, 1six, 1sjn, 1slh, 1sm8
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Deoxyuridine 5’-triphosphate nucleotidohydrolase (DUTP) catalyzes the conversion of dUTP to dUMP and pyrophosphate (PPi). DUTP plays a key role in keeping significant amounts of dUTP from the DNA synthesis pathway. DUTP inhibitors are being tested as possible anti-bacterial agents targeting diseases like malaria, leishmaniasis, tuberculosis and trypanosomiasis. Prokaryotic DUTP contains metal ion.

3D structures of dUTPase

Updated on 25-February-2014

1dup, 1eu5, 1euw – EcDUTP – Escherichia coli
1dun – EvDUTP – Equine infectious anemia virus
1mq7 – MtDUTP – Mycobacterium tuberculosis
1ogl – TcDUTP – Trypanosoma cruzi
2d4l - MPmvDUTP residues 83-234 – Mason_Pfizer monkey virus
2d4m - MPmvDUTP residues 83-234 (mutant)
2okb, 2okd - VvDUTP – Vaccinia virus
3hhq - yDUTP – yeast
3lqw - DUTP – Entamoeba histolytica
3mbq, 3mdx - DUTP – Brucella melitensis
2xx6 - BsDUTP – Bacillus subtilis
3tqz - DUTP – Coxiella burnetii
1q5u - hDUTP – human
4lhr - DUTP – Burkholderia thailandensis

DUTP binary complexes

1dud – EcDUTP + dUDP
2hrm - EcDUTP + dUTP derivative
1seh - EcDUTP + dUMP
3f4f - yDUTP + dUMP
1dut – DUTP + Mg – Feline immunodeficiency virus
1ogk – TcDUTP + dUTP
1smc - MtDUTP + dUTP
4gcy - MtDUTP (mutant) + dUTP
1vyq, 3t60, 3t64 - PfDUTP + uridine derivative inhibitor – Plasmodium falciparum
2y8c - PfDUTP + trityl ligand
2bsy, 2we0 - EbvDUTP + dUMP – Epstein-Barr virus
2we1, 2we2 - EbvDUTP (mutant) + dUMP
2ol1 - VvDUTP + dUMP
2y1t - BsDUTP + dUDP
4ao5 - BsDUTP + dUMP
2yb0 - LmDUTP + dU – Leishmania major
3tq5, 3trl, 3trn, 3ts6, 3tsl, 3tta - MPmvDUTP catalytic domain (mutant) + dUMP
2p9o, 2pc5 – DUTP + Mg – Arabidopsis thaliana
4mz5, 4mz6 – hDUTP + importin subunit α-1

DUTP ternary complexes

1duc – EvDUPT + Sr + dUTP
1six, 1sjn, 2py4 – MtDUTP + Mg + dUTP derivative
3h6d, 3hza, 3i93 - MtDUTP (mutant) + Mg + dUTP derivative
3loj - MtDUTP (mutant) + Mg + Mn + dUTP derivative
1rn8 - EcDUTP + Mg + dUTP derivative
1rnj - EcDUTP (mutant) + Mg + dUTP derivative
1syl - EcDUTP (mutant) + Mg + dUTP
2hr6 - EcDUTP + Mn + dUDP
1slh – MtDUTP + Mg + dUTP
1sm8 – MtDUTP + Cr + dUTP
1snf - MtDUTP + Mg + dUMP
1w2y, 2cic - DUTP + Mg + dUTP derivative – Campylobacter jejuni
2bt1 - EbvDUTP + Mg + dUTP derivative
2we3 - EbvDUTP residues 1-256 + Mg + dUTP
2d4n - MPmvDUTP residues 83-234 (mutant) + Mg + dUTP derivative
3tp1 - MPmvDUTP catalytic domain + Mg + dUTP derivative
3tpw, 3tpn, 3tps - MPmvDUTP catalytic domain (mutant) + Mg + dUTP derivative
3tpy, 3tq3, 3tq4 - MPmvDUTP catalytic domain + Mg + dUMP + dUTP derivative
2cje - LmDUTP + Mg + dUTP derivative
2yay - LmDUTP + Ca + dUTP derivative
2yaz - LmDUTP + Mg + dUMP
2oke - VvDUTP + Mg + dUTP derivative
2ol0 - VvDUTP + Mg + dUDP
3c3i - PbcvDUTP (mutant) + Mg + dUDP – Paramecium bursaria chlorella virus
3c2t, 3ca9 - PbcvDUTP + Mg + dUDP
2hqu - hDUTP + Mg + dUTP derivative
1q5h - hDUTP + Mg + dUDP
3ehw - hDUTP + Mg + dUTP
3ara, 3arn - hDUTP + Mg + uracil derivative
3p48 - yDUTP + Mg + dUTP derivative
2xy3 - BsDUTP + Mg + dUTP derivative
4aoo, 4apz, 4aoz - BsDUTP + Mg + PPi + uridine

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