Collagen

From Proteopedia

Jump to: navigation, search

Structure of Collagen (PDB entry 4clg or 1cag)

Drag the structure with the mouse to rotate
 

PDB ID 4clg

Drag the structure with the mouse to rotate

PDB ID 1cag

Drag the structure with the mouse to rotate
Gly Packing in 4clg ()
Ala Packing in 1cag (Mutated Collagen) ()


In order to convince yourself that there is a difference in the interchain distances in the area of the Ala, between Gly (Ala) and Pro which form intratropocollagen hydrogen bonds. Hydrogen bonds are not formed between Ala and Pro because the distances between the atoms forming the bonds are too great. The absence of the intratropocollagen hydrogen bonds, which is due to replacing Gly with a residue having a longer side chain, disrupts collagen's rope-like structure and is responsible for the symptoms of such human diseases as osteogenesis imperfecta and certain Ehlers-Danlos syndromes.

References

  1. J.M. Chen, C.E. Kung, S.H. Feairheller, E.M. Brown, AN ENERGETIC EVALUATION OF A "SMITH" COLLAGEN MICROFIBRIL MODEL, J. Protein Chem., 10, 535, 1991
  2. J.BELLA,M.EATON,B.BRODSKY,H.M.BERMAN, CRYSTAL AND MOLECULAR STRUCTURE OF A COLLAGEN-LIKE PEPTIDE AT 1.9 A RESOLUTION. SCIENCE, 266, 75, 1994

External Links

Movies of assembly of triple helix of type I and IV collagen.

Contributor

Much of the content of this page was taken from an earlier non-Proteopedia version of Collagen which was in large part developed by Gretchen Heide Bisbort, a 1999 graduate of Messiah College.

Personal tools
In other languages