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From Proteopedia

Crystal Structure of the Cell Division Protein Kinase 2, 1pw2

Cell Division Protein Kinase 2, 1pw2
Gene:	CDK2 (Homo sapiens)
Domains:	S_TKc, S_TKc
Related:	1aq1, 1b39, 1ckp, 1di8, 1dm2, 1e1v, 1e1x, 1e9h, 1fin, 1fvt, 1fvv, 1g5s, 1gih, 1gz8, 1hck, 1hcl, 1jsv, 1jvp, 1ke5, 1ke6, 1ke7, 1ke8, 1ke9
Structural annotation: Resources: CATH : 1Pw2A01, 1Pw2A02 InterPro : Ipr000719, Ipr011009, Ipr002290, Ipr008271 Pfam : PF00069 SCOP : d1pw2a_ UniProt : P24941
Functional annotation: Resources: GeneCard : CDK2 Cellular component: nucleus cytoplasm Biological process: G2/M transition of mitotic cell cycle protein amino acid phosphorylation traversing start control point of mitotic cell cycle regulation of DNA replication positive regulation of cell proliferation mitosis cell division cell cycle Molecular function: kinase activity protein binding protein kinase activity cyclin-dependent protein kinase activity transferase activity identical protein binding ATP binding nucleotide binding protein serine/threonine kinase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, PDBsum, RCSB
Coordinates:	save as pdb, mmCIF, xml

Cell Division Protein Kinase 2 or cyclin-dependent kinase 2 (CDK2) is involved in the control of the cell cycle. It interacts with the regulatory protein cyclin. Phosphorylation at Thr14 or Tyr15 inactivates it; phosphorylation at Thr160 (T160P) – activates it. The images on the left and right correspond to one representative CDK2 structure, i.e. the human Cell Division Protein Kinase 2 (1pw2).

3D Structures of Cell Division Protein Kinase 2

Update November 2011

1pw2, 1hck, 1hcl, 1b38 – hCDK2 – human
1b39 - hCDK2 T160P
3ns9, 3le6, 2xmy, 2xnb, 3lfn, 3lfq, 3lfs, 3ig7, 3igg, 3fz1, 3ezr, 3ezv, 2w1h, 2w17, 2w05, 2w06, 2r64, 2vta, 2vth, 2vti, 2vtj, 2vtl, 2vtm, 2vtn, 2vto, 2vtp, 2vtq, 2vtr, 2vts, 2vtt, 2vu3, 2vv9, 2r3f, 2r3g, 2r3h, 2r3i, 2r3j, 2r3k, 2r3l, 2r3m, 2r3n, 2r3o, 2r3p, 2r3q, 2r3r, 2j9m, 2v0d, 2duv, 2clx, 2fvd, 2a4l, 1w8c, 2a0c, 2exm, 2bpm, 2c68, 2c69, 2c6i, 2c6k, 2c6l, 2c6m, 2c6o, 2c6t, 2btr, 2bts, 2b52, 2b53, 2b54, 2b55, 2bhe, 2bhh, 1y8y, 1y91, 1wcc, 1w0x, 1pye, 1vyz, 1vyw, 1v1k, 1urw, 1pxm, 1pxn, 1pxo, 1pxp, 1r78, 1pf8, 1pxi, 1pxj, 1pxk, 1pxl, 1oiq, 1oir, 1oit, 1p2a, 1h00, 1h01, 1h07, 1h08, 1h0v, 1h0w, 1gz8, 1ke5, 1ke6, 1ke7, 1ke8, 1ke9, 1gih, 1gii, 1gij, 1jvp, 1g5s, 1jsv, 1e1v, 1e1x, 1fvt, 1fvv, 1di8, 1dm2, 1ckp, 1aq1, 3pxf, 3pxq, 3pxr, 3pxy, 3pxz, 3py0, 3py1, 3pj8, 3s2p – hCDK2 + inhibitor
2ds1 – hCDK2 (mutant) + inhibitor
1fq1 - hCDK2 +cyclin-dependent kinase inhibitor 3
1buh – hCDK2+ protein CKSHS1
1ua2 – hCDK7

CDK2+cyclin

3my5 – hCDK2 + cyclin A2
2jgz - hCDK2 T160P + cyclin B1
1w98 - hCDK2 + cyclin E1
2wma, 2wmb, 2x1n, 2wev, 2wfy, 2whb, 2v22, 2cch, 1okv, 1okw, 1ol1, 1ol2, 1urc, 1h24, 1h25, 1h26, 1h27, 1h28, 1gy3, 3qhr, 3qhw - hCDK2 + cyclin A2+peptide ligand
2wpa, 2wxv, 2wih, 2wip, 3f5x, 3eoc, 3eid, 3ej1, 2uzb, 2uzd, 2uze, 2uzl, 2uzn, 2uzo, 2uue, 2i40, 2bkz, 2c5n, 2c5o, 2c5v, 2c5x, 2c5y, 1ykr, 2c4g, 1p5e, 1pkd, 1fin – hCDK2 + cyclin A2 + inhibitor
3ddp, 3dog, 3ddq, 3bht, 3bhu, 3bhv, 2iw6, 2iw8, 2iw9, 2g9x, 2cjm, 1oi9, 1oiu, 1oiy, 1ogu, 1h1p, 1jst - hCDK2 T160P+ cyclin A2 + inhibitor
2cci, 1qmz - hCDK2 T160P + cyclin A2+peptide ligand
1h1p, 1h1q, 1h1r, 1h1s, 1e9h - hCDK2 T160P + cyclin A3 + inhibitor
1jsu - hCDK2 + cyclin A2+ protein P27