Function
CREB-binding protein or CREBBP (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. [1]
Disease
Mutations in CBP cause Rubinstein-Taybi syndrome.[2]
Structural highlights
CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 (Cys- and His-rich region 1) interacts with the N-terminal of p73.
with chain A. Water molecules are shown as red spheres.
with chain B (3p1c).[3]
3D Structures of CREB-binding protein
CREB-binding protein 3D structures
