Adenylyl cyclase

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Structure of dog adenylyl cyclase 5 (grey), rat adenylyl cyclase 2 (green), bovine guanine nucleotide-binding protein subunit α (pink) complex with ADP derivative (stick model), GDP derivative (stick model), methylpiperazinoforskolin, Ca+2, Mg+2 and Cl- ions (PDB code 3maa).

Updated on 14-August-2014

Contents

3D Structures of Adenylyl cyclase

ADCY

2ev1, 2ev2, 2ev3, 2ev4 – MtADCY N-terminal – Mycobacterium tuberculosis
1y10, 1y11 – MtADCY holoenzyme
2fjt – ADCY 4 – Yersinia pestis
1ykd – ADCY – Anabaena
1ab8 – ADCY C2 domain - rat

ADCY catalytic domain

1yk9, 1ybt, 1ybu – MtADCY catalytic domain
3r5g - ADCY catalytic domain – Pseudomonas aeruginosa
1fx2, 1fx4 - ADCY catalytic domain – Trypanosoma brucei
2bw7 - SpADCY catalytic domain+catechol estrogen – Spirulina platensis
1wc0 – SpADCY catalytic domain+methylene ATP
1wc1, 1wc3, 1wc4, 1wc5, 1wc6 - SpADCY catalytic domain+ATP derivatives
3maa – dADCY 5 (mutant)+ADCY 2 C2a+guanine nucleotide binding protein G – dog
3g82 - dADCY 5 (mutant)+ADCY 2 C1a+guanine nucleotide binding protein G
3c14, 3c15 - dADCY 5 C1a (mutant)+ADCY 2 C2a+guanine nucleotide binding protein G+PPi+ions
3c16 - dADCY 5 C1a (mutant)+ADCY 2 C2a+guanine nucleotide binding protein G+ATP+Ca
2gvd, 2gvz - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+ATP+Mn
1tl7, 1u0h - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GTP+Mn
1cs4 - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+AMP+Mg+PPI+GDP
1cul - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GDP+Mg+triphosphate
1cjk - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+ATP+Mn+Mg
1cjt - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GDP+Mn+Mg+ATP
1cju - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GDP+Mg+ATP
1cjv - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GDP+Mg+Zn+ATP
1azs - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GDP+Mg
1yrt, 1yru - ADCY catalytic domain+calmodulin C-terminal – Bordetella pertussis

ADCY anthrax edema factor associated domain

1k8t - BaADCY C-terminal - Bacillus anthracis
1lvc, 1pk0, 1s26 – BaADCY C-terminal+calmodulin+anthranyloyl ATP+Yb+Ca
1sk6 - BaADCY C-terminal+calmodulin+cAMP+PPi
1xfu - BaADCY C-terminal (mutant)+calmodulin
1xfv, 1k90 - BaADCY C-terminal+calmodulin+dATP
1xfw - BaADCY C-terminal+calmodulin+cAMP
1xfx, 1xfz - BaADCY C-terminal+calmodulin+Ca
1xfy, 1k93 - BaADCY C-terminal+calmodulin
1y0v - BaADCY C-terminal+calmodulin+PPi

References


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