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Adenylyl cyclase

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Updated on 16-October-2013

3D Structures of Adenylyl cyclase

2ev1, 2ev2, 2ev3, 2ev4 – MtADCY N-terminal – Mycobacterium tuberculosis
1y10, 1y11 – MtADCY holoenzyme
2fjt – ADCY 4 – Yersinia pestis
1ykd – ADCY – Anabaena
1ab8 – ADCY C2 domain - rat

ADCY catalytic domain

1yk9, 1ybt, 1ybu – MtADCY catalytic domain
3r5g - ADCY catalytic domain – Pseudomonas aeruginosa
1fx2, 1fx4 - ADCY catalytic domain – Trypanosoma brucei
2bw7 - SpADCY catalytic domain+catechol estrogen – Spirulina platensis
1wc0 – SpADCY catalytic domain+methylene ATP
1wc1, 1wc3, 1wc4, 1wc5, 1wc6 - SpADCY catalytic domain+ATP derivatives
3maa – dADCY 5 (mutant)+ADCY 2 C2a+guanine nucleotide binding protein G – dog
3g82 - dADCY 5 (mutant)+ADCY 2 C1a+guanine nucleotide binding protein G
3c14, 3c15 - dADCY 5 C1a (mutant)+ADCY 2 C2a+guanine nucleotide binding protein G+PPi+ions
3c16 - dADCY 5 C1a (mutant)+ADCY 2 C2a+guanine nucleotide binding protein G+ATP+Ca
2gvd, 2gvz - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+ATP+Mn
1tl7, 1u0h - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GTP+Mn
1cs4 - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+AMP+Mg+PPI+GDP
1cul - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GDP+Mg+triphosphate
1cjk - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+ATP+Mn+Mg
1cjt - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GDP+Mn+Mg+ATP
1cju - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GDP+Mg+ATP
1cjv - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GDP+Mg+Zn+ATP
1azs - dADCY 5 C1a +ADCY 2 C2a+guanine nucleotide binding protein G+GDP+Mg
1yrt, 1yru - ADCY catalytic domain+calmodulin C-terminal – Bordetella pertussis

ADCY anthrax edema factor associated domain

1k8t - BaADCY C-terminal - Bacillus anthracis
1lvc, 1pk0, 1s26 – BaADCY C-terminal+calmodulin+anthranyloyl ATP+Yb+Ca
1sk6 - BaADCY C-terminal+calmodulin+cAMP+PPi
1xfu - BaADCY C-terminal (mutant)+calmodulin
1xfv, 1k90 - BaADCY C-terminal+calmodulin+dATP
1xfw - BaADCY C-terminal+calmodulin+cAMP
1xfx, 1xfz - BaADCY C-terminal+calmodulin+Ca
1xfy, 1k93 - BaADCY C-terminal+calmodulin
1y0v - BaADCY C-terminal+calmodulin+PPi

References

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  2. 2.0 2.1 2.2 2.3 2.4 Hurley JH. Structure, mechanism, and regulation of mammalian adenylyl cyclase. J Biol Chem. 1999 Mar 19;274(12):7599-602. PMID:10075642
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Zhang G, Liu Y, Ruoho AE, Hurley JH. Structure of the adenylyl cyclase catalytic core. Nature. 1997 Mar 20;386(6622):247-53. PMID:9069282 doi:10.1038/386247a0
  4. Ketkar AD, Shenoy AR, Kesavulu MM, Visweswariah SS, Suguna K. Purification, crystallization and preliminary X-ray diffraction analysis of the catalytic domain of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):371-3. Epub 2004, Jan 23. PMID:14747729 doi:10.1107/S0907444903028002
  5. Beis I, Newsholme EA. The contents of adenine nucleotides, phosphagens and some glycolytic intermediates in resting muscles from vertebrates and invertebrates. Biochem J. 1975 Oct;152(1):23-32. PMID:1212224
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  7. Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S. Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem. 2003 Dec 5;278(49):49523-9. Epub 2003 Sep 25. PMID:14512417 doi:10.1074/jbc.M309543200
  8. 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 8.9 Linder JU, Schultz A, Schultz JE. Adenylyl cyclase Rv1264 from Mycobacterium tuberculosis has an autoinhibitory N-terminal domain. J Biol Chem. 2002 May 3;277(18):15271-6. Epub 2002 Feb 11. PMID:11839758 doi:10.1074/jbc.M200235200
  9. 9.0 9.1 9.2 Siddappa R, Martens A, Doorn J, Leusink A, Olivo C, Licht R, van Rijn L, Gaspar C, Fodde R, Janssen F, van Blitterswijk C, de Boer J. cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7281-6. Epub 2008 May 19. PMID:18490653
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  12. 12.0 12.1 Feinstein PG, Schrader KA, Bakalyar HA, Tang WJ, Krupinski J, Gilman AG, Reed RR. Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10173-7. PMID:1719547
  13. 13.0 13.1 13.2 13.3 13.4 Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR. Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science. 1997 Dec 12;278(5345):1907-16. PMID:9417641
  14. Masters SB, Sullivan KA, Miller RT, Beiderman B, Lopez NG, Ramachandran J, Bourne HR. Carboxyl terminal domain of Gs alpha specifies coupling of receptors to stimulation of adenylyl cyclase. Science. 1988 Jul 22;241(4864):448-51. PMID:2899356
  15. 15.0 15.1 15.2 15.3 15.4 Wang M, Ramos BP, Paspalas CD, Shu Y, Simen A, Duque A, Vijayraghavan S, Brennan A, Dudley A, Nou E, Mazer JA, McCormick DA, Arnsten AF. Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell. 2007 Apr 20;129(2):397-410. PMID:17448997 doi:10.1016/j.cell.2007.03.015
  16. 16.00 16.01 16.02 16.03 16.04 16.05 16.06 16.07 16.08 16.09 16.10 16.11 16.12 16.13 16.14 16.15 16.16 16.17 16.18 16.19 16.20 16.21 16.22 16.23 16.24 16.25 16.26 16.27 16.28 16.29 16.30 16.31 16.32 16.33 16.34 16.35 16.36 Tews I, Findeisen F, Sinning I, Schultz A, Schultz JE, Linder JU. The structure of a pH-sensing mycobacterial adenylyl cyclase holoenzyme. Science. 2005 May 13;308(5724):1020-3. PMID:15890882 doi:http://dx.doi.org/308/5724/1020
  17. 17.0 17.1 17.2 Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR. Two-metal-Ion catalysis in adenylyl cyclase. Science. 1999 Jul 30;285(5428):756-60. PMID:10427002
  18. Tesmer JJ, Dessauer CW, Sunahara RK, Murray LD, Johnson RA, Gilman AG, Sprang SR. Molecular basis for P-site inhibition of adenylyl cyclase. Biochemistry. 2000 Nov 28;39(47):14464-71. PMID:11087399
  19. 19.0 19.1 19.2 19.3 19.4 19.5 19.6 19.7 19.8 Findeisen F, Linder JU, Schultz A, Schultz JE, Brugger B, Wieland F, Sinning I, Tews I. The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid. J Mol Biol. 2007 Jun 22;369(5):1282-95. Epub 2007 Apr 12. PMID:17482646 doi:10.1016/j.jmb.2007.04.013
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  23. Lowrie DB, Jackett PS, Ratcliffe NA. Mycobacterium microti may protect itself from intracellular destruction by releasing cyclic AMP into phagosomes. Nature. 1975 Apr 17;254(5501):600-2. PMID:165421
  24. Rickman L, Scott C, Hunt DM, Hutchinson T, Menendez MC, Whalan R, Hinds J, Colston MJ, Green J, Buxton RS. A member of the cAMP receptor protein family of transcription regulators in Mycobacterium tuberculosis is required for virulence in mice and controls transcription of the rpfA gene coding for a resuscitation promoting factor. Mol Microbiol. 2005 Jun;56(5):1274-86. PMID:15882420 doi:10.1111/j.1365-2958.2005.04609.x

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