Structural highlights
Function
SPUE_PSEAE Spermidine-binding protein probably required for its uptake into cells. Binds spermidine with high affinity (KD=14.3 nM). Does not bind putrescine, cadaverine or spermine. Spermidine binding induces large inter-domain conformational changes. Implicated in induction of type 3 secretion systems (T3SS), which play a role in virulence.[1]
See Also
References
- ↑ Wu D, Lim SC, Dong Y, Wu J, Tao F, Zhou L, Zhang LH, Song H. Structural Basis of Substrate Binding Specificity Revealed by the Crystal Structures of Polyamine Receptors SpuD and SpuE from Pseudomonas aeruginosa. J Mol Biol. 2012 Mar 9;416(5):697-712. Epub 2012 Jan 28. PMID:22300763 doi:10.1016/j.jmb.2012.01.010
