6csu
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proteopedia linkproteopedia linkThe structure of the Cep63-Cep152 heterotetrameric complex
Structural highlights
DiseaseCE152_HUMAN Seckel syndrome;Autosomal recessive primary microcephaly. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. FunctionCE152_HUMAN Necessary for centrosome duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles.[1] [2] [3] References
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Categories: Homo sapiens | Large Structures | Ahn JI | Chen Y | Kim TS | Lee E | Lee KS | Park JE | Zhang L