5i44

Structural highlights

Function

RACA_BACSU Required for the formation of axial filaments and for anchoring the origin regions at the cell poles in sporulating cells, thus ensuring proper chromosome segregation in the prespore. Binds in a dispersed manner throughout the chromosome but preferentially to sites clustered in the origin portion of the chromosome, causing condensation of the chromosome and its remodeling into an elongated, anchored structure.^{[1] [2]}

References

1. ↑ Ben-Yehuda S, Rudner DZ, Losick R. RacA, a bacterial protein that anchors chromosomes to the cell poles. Science. 2003 Jan 24;299(5606):532-6. Epub 2002 Dec 19. PMID:12493822 doi:http://dx.doi.org/10.1126/science.1079914
2. ↑ Wu LJ, Errington J. RacA and the Soj-Spo0J system combine to effect polar chromosome segregation in sporulating Bacillus subtilis. Mol Microbiol. 2003 Sep;49(6):1463-75. PMID:12950914