4g85
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proteopedia linkproteopedia linkCrystal structure of human HisRS
Structural highlights
DiseaseHARS1_HUMAN Usher syndrome type 3;Autosomal dominant Charcot-Marie-Tooth disease type 2W. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. FunctionHARS1_HUMAN Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP) (PubMed:29235198). Plays a role in axon guidance (PubMed:26072516).[1] [2] See AlsoReferences
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Categories: Homo sapiens | Large Structures | Schimmel P | Wei Z | Wu J | Yang X-L | Zhang M | Zhou JJ