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4fru

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4fru, resolution 1.10Å ()
Ligands: , ,
Gene: PPIB (Equus caballus)
Activity: Peptidylprolyl isomerase, with EC number 5.2.1.8


Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Crystal structure of horse wild-type cyclophilin B

Publication Abstract from PubMed

ABSTRACT: BACKGROUND: Hyperelastosis cutis is an inherited autosomal recessive connective tissue disorder. Affected horses are characterized by hyperextensible skin, scarring, and severe lesions along the back. The disorder is caused by a mutation in cyclophilin B. RESULTS: The crystal structures of both wild-type and mutated (Gly6->Arg) horse cyclophilin B are presented. The mutation neither affects the overall fold of the enzyme nor impairs the catalytic site structure. Instead, it locally rearranges the flexible N-terminal end of the polypeptide chain and also makes it more rigid. CONCLUSIONS: Interactions of the mutated cyclophilin B with a set of endoplasmic reticulum-resident proteins must be affected.

Crystal structures of wild-type and mutated cyclophilin B that causes hyperelastosis cutis in the American quarter horse., Boudko SP, Ishikawa Y, Lerch TF, Nix J, Chapman MS, Bachinger HP, BMC Res Notes. 2012 Nov 8;5:626. doi: 10.1186/1756-0500-5-626. PMID:23137129

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

4fru is a 1 chain structure with sequence from Equus caballus. Full crystallographic information is available from OCA.

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