Structural highlights
Function
ZSC10_MOUSE Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4.[1] [2] [3]
References
- ↑ Zhang W, Walker E, Tamplin OJ, Rossant J, Stanford WL, Hughes TR. Zfp206 regulates ES cell gene expression and differentiation. Nucleic Acids Res. 2006;34(17):4780-90. Epub 2006 Sep 13. PMID:16971461 doi:http://dx.doi.org/gkl631
- ↑ Wang ZX, Kueh JL, Teh CH, Rossbach M, Lim L, Li P, Wong KY, Lufkin T, Robson P, Stanton LW. Zfp206 is a transcription factor that controls pluripotency of embryonic stem cells. Stem Cells. 2007 Sep;25(9):2173-82. doi: 10.1634/stemcells.2007-0085. Epub 2007, Jul 12. PMID:17628018 doi:http://dx.doi.org/10.1634/stemcells.2007-0085
- ↑ Yu HB, Kunarso G, Hong FH, Stanton LW. Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells. J Biol Chem. 2009 Nov 6;284(45):31327-35. doi: 10.1074/jbc.M109.016162. Epub 2009, Sep 9. PMID:19740739 doi:http://dx.doi.org/10.1074/jbc.M109.016162
