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3tgf
From Proteopedia
| 3tgf, 4 NMR models () | |||||||||
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| Related: | 2tgf | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
THE SOLUTION STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA
The solution structure of transforming growth factor alpha has been determined by a combination of high-resolution 1H-nuclear magnetic resonance and distance geometry and restrained molecular dynamics. The 382 restraints derived from the NMR experiments were used to calculate many distance geometry structures, which were then refined by restrained molecular mechanics. Five of these structures were further refined using a variety of methods. Comparison of independently measured parameters, such as calculated hydrogen bonding patterns and experimental amide exchange rates, have been used to evaluate the accuracy of the structures. Also, possible mechanisms to explain the pH-dependent conformational interconversion observed are suggested. Finally comparisons between this work and others on this topic have been made.
The solution structure of human transforming growth factor alpha., Harvey TS, Wilkinson AJ, Tappin MJ, Cooke RM, Campbell ID, Eur J Biochem. 1991 Jun 15;198(3):555-62. PMID:2050136
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
3TGF is a 1 chain structure of sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Harvey TS, Wilkinson AJ, Tappin MJ, Cooke RM, Campbell ID. The solution structure of human transforming growth factor alpha. Eur J Biochem. 1991 Jun 15;198(3):555-62. PMID:2050136
Page seeded by OCA on Wed Feb 18 00:31:38 2009
