|3sil, resolution 1.05Å ()|
|Gene:||NANH (Salmonella enterica subsp. enterica serovar Typhimurium)|
SIALIDASE FROM SALMONELLA TYPHIMURIUM
To understand the role of aromatic-aromatic interactions in imparting specificity to the folding process, the geometries of four aromatic residues with different sequence spacing, located in alpha-helices or five residues from helical ends, interacting with each other have been elucidated. The geometry is found to depend on the sequence difference. Specific interactions (C-H...pi and N-H...pi) which result from this geometry may cause a given pair of residues (such as Phe-His) with a particular sequence difference to occur more than expected. The most conspicuous residue in an aromatic pair in the context of helix stability is His, which is found at the last (C1) position or the two positions (Ncap and Ccap) immediately flanking the helix. An alpha-helix and a contiguous 3(10)-helix or two helices separated by a non-helical residue can have interacting aromatic pairs, the geometry of interaction and the relative orientation between the helices being rather fixed. Short helices can also have interacting residues from either side.
Aromatic-aromatic interactions in and around alpha-helices., Bhattacharyya R, Samanta U, Chakrabarti P, Protein Eng. 2002 Feb;15(2):91-100. PMID:011917145
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
3sil is a 1 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhimurium. Full crystallographic information is available from OCA.
- Bhattacharyya R, Samanta U, Chakrabarti P. Aromatic-aromatic interactions in and around alpha-helices. Protein Eng. 2002 Feb;15(2):91-100. PMID:11917145