Structural highlights
3rj8 is a 1 chain structure with sequence from Microdochium nivale. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.4Å |
| Ligands: | , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
MNCO_MICNN Catalyzes the selective oxidation of C1 hydroxyl moieties on mono-, oligo- and polysaccharides with concomitant reduction of molecular oxygen to hydrogen peroxide. This results in the formation of the corresponding lactones, which typically undergo spontaneous hydrolysis. Carbohydrate oxidase is able to oxidize a variety of substrates including D-glucose, D-galactose, D-xylose, D-maltose, D-cellobiose, and lactose. In addition, among various oligosaccharides, the enzyme preferred tetrameric dextrins, indicating a favorable interaction of four linked glucose units with the substrate binding pocket.[1] [PROSITE-ProRule:PRU00718][2]
References
- ↑ Xu F, Golightly EJ, Fuglsang CC, Schneider P, Duke KR, Lam L, Christensen S, Brown KM, Jørgensen CT, Brown SH. A novel carbohydrate:acceptor oxidoreductase from Microdochium nivale. Eur J Biochem. 2001 Feb;268(4):1136-42. PMID:11179980 doi:10.1046/j.1432-1327.2001.01982.x
- ↑ Xu F, Golightly EJ, Fuglsang CC, Schneider P, Duke KR, Lam L, Christensen S, Brown KM, Jørgensen CT, Brown SH. A novel carbohydrate:acceptor oxidoreductase from Microdochium nivale. Eur J Biochem. 2001 Feb;268(4):1136-42. PMID:11179980 doi:10.1046/j.1432-1327.2001.01982.x
