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3o5h, resolution 4.00Å ()
Non-Standard Residues:
Related: 3o2z, 3o30, 3o58

Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Yeast 80S ribosome. This entry consists of the 60S subunit of the second 80S in the asymmetric unit.

Publication Abstract from PubMed

Crystal structures of prokaryotic ribosomes have described in detail the universally conserved core of the translation mechanism. However, many facets of the translation process in eukaryotes are not shared with prokaryotes. The crystal structure of the yeast 80S ribosome determined at 4.15 angstrom resolution reveals the higher complexity of eukaryotic ribosomes, which are 40% larger than their bacterial counterparts. Our model shows how eukaryote-specific elements considerably expand the network of interactions within the ribosome and provides insights into eukaryote-specific features of protein synthesis. Our crystals capture the ribosome in the ratcheted state, which is essential for translocation of mRNA and transfer RNA (tRNA), and in which the small ribosomal subunit has rotated with respect to the large subunit. We describe the conformational changes in both ribosomal subunits that are involved in ratcheting and their implications in coordination between the two associated subunits and in mRNA and tRNA translocation.

Crystal structure of the eukaryotic ribosome., Ben-Shem A, Jenner L, Yusupova G, Yusupov M, Science. 2010 Nov 26;330(6008):1203-9. PMID:21109664

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

3o5h is a 40 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

See Also


  • Ben-Shem A, Jenner L, Yusupova G, Yusupov M. Crystal structure of the eukaryotic ribosome. Science. 2010 Nov 26;330(6008):1203-9. PMID:21109664 doi:10.1126/science.1194294

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