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|3k3p, resolution 2.23Å ()|
|Gene:||ddl (Streptococcus mutans)|
Crystal Structure of the Apo Form of D-Alanine:D-Alanine Ligase (DDl) from Streptococcus mutans
D-Alanine:D-Alanine ligase (DDl) catalyzes the formation of D-Alanine:D-Alanine dipeptide and is an essential enzyme in bacterial cell wall biosynthesis.. This enzyme does not have a human ortholog, making it an attractive target for developing new antibiotic drugs. We determined the crystal structure at 2.23 A resolution of DDl from Streptococcus mutans (SmDDl), the principal aetiological agent of human dental caries. This structure reveals that SmDDl is a dimer and has a disordered omega-loop region.
Crystal structure of the Apo form of D-Alanine:D-Alanine ligase (DDl) from Streptococcus mutans., Lu Y, Xu H, Zhao X, Protein Pept Lett. 2010;17(8):1053-7. PMID:20522004
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
- Lu Y, Xu H, Zhao X. Crystal structure of the Apo form of D-Alanine:D-Alanine ligase (DDl) from Streptococcus mutans. Protein Pept Lett. 2010;17(8):1053-7. PMID:20522004