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3k3p

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3k3p, resolution 2.23Å ()
Gene: ddl (Streptococcus mutans)
Activity: D-alanine--D-alanine ligase, with EC number 6.3.2.4


Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Crystal Structure of the Apo Form of D-Alanine:D-Alanine Ligase (DDl) from Streptococcus mutans

Publication Abstract from PubMed

D-Alanine:D-Alanine ligase (DDl) catalyzes the formation of D-Alanine:D-Alanine dipeptide and is an essential enzyme in bacterial cell wall biosynthesis.. This enzyme does not have a human ortholog, making it an attractive target for developing new antibiotic drugs. We determined the crystal structure at 2.23 A resolution of DDl from Streptococcus mutans (SmDDl), the principal aetiological agent of human dental caries. This structure reveals that SmDDl is a dimer and has a disordered omega-loop region.

Crystal structure of the Apo form of D-Alanine:D-Alanine ligase (DDl) from Streptococcus mutans., Lu Y, Xu H, Zhao X, Protein Pept Lett. 2010;17(8):1053-7. PMID:20522004

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

3k3p is a 2 chain structure with sequence from Streptococcus mutans. Full crystallographic information is available from OCA.

Reference

  • Lu Y, Xu H, Zhao X. Crystal structure of the Apo form of D-Alanine:D-Alanine ligase (DDl) from Streptococcus mutans. Protein Pept Lett. 2010;17(8):1053-7. PMID:20522004

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