3jz4

Structural highlights

Function

GABD_ECOLI Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. It appears to be important for nitrogen metabolism under N limitation conditions.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Aldehyde dehydrogenase 3D structures
• Succinate-semialdehyde dehydrogenase

References

1. ↑ Langendorf CG, Key TL, Fenalti G, Kan WT, Buckle AM, Caradoc-Davies T, Tuck KL, Law RH, Whisstock JC. The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions. PLoS One. 2010 Feb 18;5(2):e9280. PMID:20174634 doi:10.1371/journal.pone.0009280
2. ↑ Donnelly MI, Cooper RA. Succinic semialdehyde dehydrogenases of Escherichia coli: their role in the degradation of p-hydroxyphenylacetate and gamma-aminobutyrate. Eur J Biochem. 1981 Jan;113(3):555-61. PMID:7011797