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3hsc
From Proteopedia
| 3hsc, resolution 1.93Å () | |||||||||
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| Ligands: | , , , | ||||||||
| Activity: | Adenosinetriphosphatase, with EC number 3.6.1.3 | ||||||||
| Domains: | HSP70 | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN
The three-dimensional structure of the amino-terminal 44K ATPase fragment of the 70K bovine heat-shock cognate protein has been solved to a resolution of 2.2 A. The ATPase fragment has two structural lobes with a deep cleft between them; ATP binds at the base of the cleft. Surprisingly, the nucleotide-binding 'core' of the ATPase fragment has a tertiary structure similar to that of hexokinase, although the remainder of the structures of the two proteins are completely dissimilar, suggesting that both the phosphotransferase mechanism and the substrate-induced conformational change intrinsic to the hexokinases may be used by the 70K heat shock-related proteins.
Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein., Flaherty KM, DeLuca-Flaherty C, McKay DB, Nature. 1990 Aug 16;346(6285):623-8. PMID:2143562
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
3HSC is a 1 chain structure of sequence from Bos taurus. This structure supersedes the now removed PDB entries and 1hsc. Full crystallographic information is available from OCA.
Reference
- Flaherty KM, DeLuca-Flaherty C, McKay DB. Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein. Nature. 1990 Aug 16;346(6285):623-8. PMID:2143562 doi:10.1038/346623a0
Page seeded by OCA on Tue Feb 17 04:54:14 2009
