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3dtu

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3dtu, resolution 2.15Å ()
Ligands: , , , , , , , , , ,
Gene: ctaD (Rhodobacter sphaeroides), ctaC, coxII, ctaB (Rhodobacter sphaeroides)
Activity: Cytochrome-c oxidase, with EC number 1.9.3.1
Related: 2gsm
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Contents

Catalytic core subunits (I and II) of cytochrome c oxidase from Rhodobacter sphaeroides complexed with deoxycholic acid

Publication Abstract from PubMed

Micromolar concentrations of the bile salt deoxycholate are shown to rescue the activity of an inactive mutant, E101A, in the K proton pathway of Rhodobacter sphaeroides cytochrome c oxidase. A crystal structure of the wild-type enzyme reveals, as predicted, deoxycholate bound with its carboxyl group at the entrance of the K path. Since cholate is a known potent inhibitor of bovine oxidase and is seen in a similar position in the bovine structure, the crystallographically defined, conserved steroid binding site could reveal a regulatory site for steroids or structurally related molecules that act on the essential K proton path.

A conserved steroid binding site in cytochrome C oxidase., Qin L, Mills DA, Buhrow L, Hiser C, Ferguson-Miller S, Biochemistry. 2008 Sep 23;47(38):9931-3. Epub 2008 Aug 30. PMID:18759498

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

3dtu is a 4 chain structure with sequence from Rhodobacter sphaeroides. Full crystallographic information is available from OCA.

See Also

Reference

  • Qin L, Mills DA, Buhrow L, Hiser C, Ferguson-Miller S. A conserved steroid binding site in cytochrome C oxidase. Biochemistry. 2008 Sep 23;47(38):9931-3. Epub 2008 Aug 30. PMID:18759498 doi:10.1021/bi8013483

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