Structural highlights
Function
FHOD1_HUMAN Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.[1] [2] [3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Takeya R, Sumimoto H. Fhos, a mammalian formin, directly binds to F-actin via a region N-terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formation. J Cell Sci. 2003 Nov 15;116(Pt 22):4567-75. PMID:14576350 doi:http://dx.doi.org/10.1242/jcs.00769
- ↑ Gasteier JE, Schroeder S, Muranyi W, Madrid R, Benichou S, Fackler OT. FHOD1 coordinates actin filament and microtubule alignment to mediate cell elongation. Exp Cell Res. 2005 May 15;306(1):192-202. PMID:15878344 doi:http://dx.doi.org/S0014-4827(05)00052-2
- ↑ Hannemann S, Madrid R, Stastna J, Kitzing T, Gasteier J, Schonichen A, Bouchet J, Jimenez A, Geyer M, Grosse R, Benichou S, Fackler OT. The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing. J Biol Chem. 2008 Oct 10;283(41):27891-903. doi: 10.1074/jbc.M801800200. Epub, 2008 Aug 11. PMID:18694941 doi:10.1074/jbc.M801800200
