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3d32
From Proteopedia
| 3d32, resolution 1.30Å () | |||||||||
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| Sites: | , , , , , , , , , and | ||||||||
| Ligands: | , , | ||||||||
| Gene: | GABARAP, FLC3B (Homo sapiens) | ||||||||
| Domains: | GABARAP | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Complex of GABA(A) receptor-associated protein (GABARAP) with a synthetic peptide
The gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein is a versatile adaptor protein playing an important role in intracellular vesicle trafficking, particularly in neuronal cells. We present the X-ray structure of the soluble form of human GABA(A) receptor-associated protein complexed with a high-affinity synthetic peptide at 1.3 A resolution. The data shed light on the probable binding modes of key interaction partners, including the GABA(A) receptor and the cysteine protease Atg4. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.
Ligand Binding Mode of GABA(A) Receptor-Associated Protein., Weiergraber OH, Stangler T, Thielmann Y, Mohrluder J, Wiesehan K, Willbold D, J Mol Biol. 2008 Jul 7. PMID:18638487
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
3D32 is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Weiergraber OH, Stangler T, Thielmann Y, Mohrluder J, Wiesehan K, Willbold D. Ligand binding mode of GABAA receptor-associated protein. J Mol Biol. 2008 Sep 19;381(5):1320-31. Epub 2008 Jul 7. PMID:18638487 doi:10.1016/j.jmb.2008.06.086
Page seeded by OCA on Wed Feb 18 09:44:27 2009
