3czv

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3czv, resolution 2.00Å ()
Ligands: , ,
Gene: CA13 (Homo sapiens)
Activity: Carbonate dehydratase, with EC number 4.2.1.1
Related: 1ca2
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Contents

Crystal structure of the human carbonic anhydrase XIII in complex with acetazolamide

Publication Abstract from PubMed

The cytosolic isoform XIII is a recently discovered member of the human carbonic anhydrase (hCA, EC 4.2.1.1) family. It is selectively expressed among other tissues in the reproductive organs, where it may control pH and ion balance regulation, ensuring thus proper fertilization conditions. The authors report here the X-ray crystallographic structure of this isozyme in the unbound state and in complex with a classical sulfonamide inhibitor, namely acetazolamide. A detailed comparison of the obtained structural data with those already reported for other CA isozymes provides novel insights into the catalytic properties of the members of this protein family. On the basis of the inhibitory properties of acetazolamide against various cytosolic/transmembrane isoforms and the structural differences detected within the active site of the various CA isoforms, further prospects for the design of isozyme-specific CA inhibitors are here proposed. Proteins 2008. (c) 2008 Wiley-Liss, Inc.

Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide., Di Fiore A, Monti SM, Hilvo M, Parkkila S, Romano V, Scaloni A, Pedone C, Scozzafava A, Supuran CT, De Simone G, Proteins. 2008 Jul 10. PMID:18618712

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Function

[CAH13_HUMAN] Reversible hydration of carbon dioxide.

About this Structure

3czv is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Di Fiore A, Monti SM, Hilvo M, Parkkila S, Romano V, Scaloni A, Pedone C, Scozzafava A, Supuran CT, De Simone G. Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. Proteins. 2008 Jul 10. PMID:18618712 doi:10.1002/prot.22144

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