3bt8

From Proteopedia

Jump to: navigation, search


3bt8, resolution 2.70Å ()
Activity: Peptidylprolyl isomerase, with EC number 5.2.1.8
Related: 2haq
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Contents

Crystal Structure of Mutant Cyclophilin (R147A) from Leishmania donovani

Publication Abstract from PubMed

The crystal structure of cyclophilin from Leishmania donovani (LdCyp) has been determined and refined at 1.97 A resolution to a crystallographic R factor of 0.178 (R(free) = 0.197). The structure was solved by molecular replacement using cyclophilin from Trypanosoma cruzi as the search model. LdCyp exhibits complete structural conservation of the cyclosporin-binding site with respect to the homologous human protein, as anticipated from LdCyp-cyclosporin binding studies. Comparisons with other cyclophilins show deviations primarily in the loop regions. The solvent structure encompassing the molecule has also been analyzed in some detail.

Structure of cyclophilin from Leishmania donovani at 1.97 A resolution., Venugopal V, Sen B, Datta AK, Banerjee R, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Feb 1;63(Pt, 2):60-4. Epub 2007 Jan 17. PMID:17277440

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

3bt8 is a 1 chain structure with sequence from Leishmania donovani. Full crystallographic information is available from OCA.

See Also

Reference

  • Venugopal V, Sen B, Datta AK, Banerjee R. Structure of cyclophilin from Leishmania donovani at 1.97 A resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Feb 1;63(Pt, 2):60-4. Epub 2007 Jan 17. PMID:17277440 doi:10.1107/S1744309106056351
  • Sen B, Venugopal V, Chakraborty A, Datta R, Dolai S, Banerjee R, Datta AK. Amino acid residues of Leishmania donovani cyclophilin key to interaction with its adenosine kinase: biological implications. Biochemistry. 2007 Jul 3;46(26):7832-43. Epub 2007 Jun 7. PMID:17552497 doi:10.1021/bi602625h

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools