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2zv6
From Proteopedia
| 2zv6, resolution 2.70Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene: | SERPINB3, SCCA, SCCA1 (Homo sapiens) | ||||||||
| |||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Crystal structure of human squamous cell carcinoma antigen 1
Squamous cell carcinoma antigen 1 (SCCA1), which belongs to serine proteinase inhibitor (serpin) superfamily, inhibits papain-like cysteine proteinase. Recently, it has been reported that SCCA1 acts not only as a proteinase inhibitor but also as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). The present study determined the crystal structure of SCCA1, suggesting that the reactive center loop (RCL) of SCCA1, a recognition site of proteinase, is very flexible and located away form the main-body of SCCA1. We show that the inhibitory effect of SCCA1 on the kinase activity of JNK1 is lost when the RCL was truncated. Furthermore, we found that a mutant protein created by replacing one amino acid in RCL maintain the suppressive activity to JNK1, whereas the inhibitory effect to proteinase is obviously decreased.
Crystal structure of SCCA1 and insight about the interaction with JNK1., Zheng B, Matoba Y, Kumagai T, Katagiri C, Hibino T, Sugiyama M, Biochem Biophys Res Commun. 2009 Feb 27;380(1):143-7. Epub 2009 Jan 21. PMID:19166818
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2ZV6 is a 3 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zheng B, Matoba Y, Kumagai T, Katagiri C, Hibino T, Sugiyama M. Crystal structure of SCCA1 and insight about the interaction with JNK1. Biochem Biophys Res Commun. 2009 Feb 27;380(1):143-7. Epub 2009 Jan 21. PMID:19166818 doi:S0006-291X(09)00095-3
Page seeded by OCA on Wed Sep 22 11:47:26 2010
