Structural highlights
Function
[ZN473_HUMAN] Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.[1] [2] [3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Dominski Z, Erkmann JA, Yang X, Sanchez R, Marzluff WF. A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. Genes Dev. 2002 Jan 1;16(1):58-71. PMID:11782445 doi:http://dx.doi.org/10.1101/gad.932302
- ↑ Wagner EJ, Marzluff WF. ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase. Mol Cell Biol. 2006 Sep;26(17):6702-12. PMID:16914750 doi:http://dx.doi.org/26/17/6702
- ↑ Wagner EJ, Ospina JK, Hu Y, Dundr M, Matera AG, Marzluff WF. Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein. RNA. 2006 Jul;12(7):1206-18. Epub 2006 May 18. PMID:16714279 doi:http://dx.doi.org/rna.2606
