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2w0t
From Proteopedia
| 2w0t, 20 NMR models () | |||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
SOLUTION STRUCTURE OF THE FCS ZINC FINGER DOMAIN OF HUMAN LMBL2
Polycomb group proteins are epigenetic regulators that maintain patterns of gene expression over multiple rounds of cell division. Many of these proteins, including polyhomeotic and the MBT repeat containing proteins SCM and dSfmbt, contain an atypical C2C2 zinc finger with a characteristic phenylalanine-cysteine-serine sequence motif. The reoccurrence of this so-called FCS zinc finger in a variety of polycomb group proteins suggests that it has an important regulatory function. We have determined the solution structure of the FCS zinc finger of the human dSfmbt homologue L(3)mbt-like 2 (L3MBTL2). The structure consists of a beta-hairpin followed by an alpha-helix. The zinc ligands are situated in the beta-hairpin and at the N-terminus of the alpha-helix an arrangement typical of the treble clef class of zinc fingers. The structure is consistent with the proposal that FCS zinc fingers bind to regulatory RNAs.
Solution structure of the FCS zinc finger domain of the human polycomb group protein L(3)mbt-like 2., Lechtenberg BC, Allen MD, Rutherford TJ, Freund SM, Bycroft M, Protein Sci. 2009 Mar;18(3):657-61. PMID:19241375
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2W0T is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Lechtenberg BC, Allen MD, Rutherford TJ, Freund SM, Bycroft M. Solution structure of the FCS zinc finger domain of the human polycomb group protein L(3)mbt-like 2. Protein Sci. 2009 Mar;18(3):657-61. PMID:19241375 doi:10.1002/pro.51
Page seeded by OCA on Wed Sep 22 11:58:38 2010
Categories: Homo sapiens | Allen, M D. | Bycroft, M. | Lechtenberg, B C. | Alternative splicing | Chromatin regulator | Lmbl2 | Mbt repeat | Metal-binding | Mym zinc finger | Nucleus | Pcg protein | Phosphoprotein | Polycomb group | Polymorphism | Rna binding | Transcription | Transcription regulation | Treble clef fold | Yacg | Zinc | Zinc-finger
