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2vk0
From Proteopedia
| 2vk0, resolution 2.20Å () | |
|---|---|
| Sites: | , , , and |
| Ligands: | , |
| Related: | 1ai0, 1aiy, 1ben, 1ev3, 1ev6, 1g7b, 1hiq, 1hit, 1hls, 1htv, 1hui, 1ioh, 1j73, 1jco, 1lkq, 1mhi, 1mso, 1os4, 1q4v, 1qiz, 1qj0, 1tym, 1vkt, 1w8p, 1xda, 1znj, 1a7f, 1b9e, 1efe, 1evr, 1fu2, 1fub, 1g7a, 1guj, 1his, 1iog, 1jca, 1k3m, 1kmf, 1lph, 1mhj, 1os3, 1qiy, 1rwe, 1sf1, 1sjt, 1t0c, 1t1k, 1t1p, 2ceu, 2hiu, 3aiy, 4aiy, 5aiy, 1t1q, 1trz, 1tyl, 1uz9, 1xgl, 1xw7, 1zeg, 1zeh, 2aiy, 2c8q, 2c8r, 2h67, 2hh4, 2hho, 2vjz |
| Resources: | FirstGlance, OCA, PDBsum, RCSB |
| Coordinates: | save as pdb, mmCIF, xml |
CRYSTAL STRUCTURE FORM ULTALENTE INSULIN MICROCRYSTALS
Ultralente insulin has been one of the commercially most important insulin preparations in diabetes treatment over the last 50 years. It is a suspension of insulin microcrystals which dissolve slowly following subcutaneous injection. Because of the small crystal size of about 25 x 25 x 5 mum(3) the atomic structure has been elusive until now. Here we present the crystal structures from Ultralente and their precursor microcrystals from the industrial manufacturing process. During this process insulin undergoes a conformational change within the microcrystals. Both structures show canonical folding of the insulin molecules but exhibit a number of new features when compared with other insulin structures. Surprisingly, we found that the Ultralente crystals bind the conservation agent methylparaben, which slows down dissolution of the crystals and thus contributes to the long duration of action. Proteins 2008. (c) 2008 Wiley-Liss, Inc.
Crystal structure of Ultralente-A microcrystalline insulin suspension., Wagner A, Diez J, Schulze-Briese C, Schluckebier G, Proteins. 2008 Sep 2. PMID:18767151
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2VK0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of Ultralente-A microcrystalline insulin suspension., Wagner A, Diez J, Schulze-Briese C, Schluckebier G, Proteins. 2008 Sep 2. PMID:18767151
Page seeded by OCA on Wed Sep 17 13:37:14 2008
Categories: Homo sapiens | Single protein | Diez, J. | Schluckebier, G. | Schulze-Briese, C. | Wagner, A. | Carbohydrate metabolism | Cleavage on pair of basic residue | Diabetes mellitus | Disease mutation | Glucose metabolism | Hormone | Insulin | Micro crystal | Micro focus beamline | Pharmaceutical | Secreted
