Structural highlights
Function
CATL1_HUMAN Important for the overall degradation of proteins in lysosomes.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5 A crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.
Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras.,Fairhead M, Johnson KA, Kowatz T, McMahon SA, Carter LG, Oke M, Liu H, Naismith JH, van der Walle CF Chem Commun (Camb). 2008 Apr 21;(15):1765-7. Epub 2008 Feb 11. PMID:18379686[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Fairhead M, Johnson KA, Kowatz T, McMahon SA, Carter LG, Oke M, Liu H, Naismith JH, van der Walle CF. Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras. Chem Commun (Camb). 2008 Apr 21;(15):1765-7. Epub 2008 Feb 11. PMID:18379686 doi:http://dx.doi.org/10.1039/b718264c