First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.

2v2x

From Proteopedia

Jump to: navigation, search
2v2x, resolution 1.60Å ()
Related: 1akj, 1ao7, 1aqd, 1b0g, 1b0r, 1bd2, 1duy, 1duz, 1eey, 1eez, 1hhg, 1hhh, 1hhi, 1hhj, 1hhk, 1hla, 1i1f, 1i1y, 1i4f, 1i7r, 1i7t, 1i7u, 1im3, 1jf1, 1jht, 1lp9, 1oga, 1p7q, 1qew, 1qr1, 1qrn, 1qse, 1qsf, 1s8d, 1s9w, 1s9x, 1s9y, 1t1w, 1t1x, 1t1y, 1t1z, 1t20, 1t21, 1t22, 1tvb, 1tvh, 1ur7, 2av1, 2av7, 2bnq, 2bnr, 2bsu, 2bsv, 2c7u, 2clr, 2gj6, 2jcc, 2uwe, 3hla, 1a1m, 1a1n, 1a1o, 1a6z, 1a9b, 1a9e, 1agb, 1agc, 1agd, 1age, 1agf, 1c16, 1ce6, 1cg9, 1de4, 1e27, 1e28, 1efx, 1exu, 1gzp, 1gzq, 1hsa, 1hsb, 1im9, 1jgd, 1jge, 1jnj, 1k5n, 1kpr, 1ktl, 1lds, 1m05, 1m6o, 1mhe, 1mi5, 1n2r, 1of2, 1ogt, 1onq, 1py4, 1q94, 1qlf, 1qqd, 1qvo, 1r3h, 1sys, 1syv, 1tmc, 1uqs, 1uxs, 1uxw, 1vgk, 1w0v, 1w0w, 1w72, 1x7q, 1xh3, 1xr8, 1xr9, 1xz0, 1ydp, 1ypz, 1zs8, 1zsd, 1zt4, 2a83, 2ak4, 2axf, 2axg, 2bck, 2bsr, 2bss, 2bst, 2bvq, 2cii, 2cik, 2d31, 2esv, 2f74, 2f8o, 2h26, 2hjk, 2hjl, 2hla, 2v2w
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Contents

T CELL CROSS-REACTIVITY AND CONFORMATIONAL CHANGES DURING TCR ENGAGEMENT.

Publication Abstract from PubMed

All thymically selected T cells are inherently cross-reactive, yet many data indicate a fine specificity in antigen recognition, which enables virus escape from immune control by mutation in infections such as the human immunodeficiency virus (HIV). To address this paradox, we analyzed the fine specificity of T cells recognizing a human histocompatibility leukocyte antigen (HLA)-A2-restricted, strongly immunodominant, HIV gag epitope (SLFNTVATL). The majority of 171 variant peptides tested bound HLA-A2, but only one third were recognized. Surprisingly, one recognized variant (SLYNTVATL) showed marked differences in structure when bound to HLA-A2. T cell receptor (TCR) recognition of variants of these two peptides implied that they adopted the same conformation in the TCR-peptide-major histocompatibility complex (MHC) complex. However, the on-rate kinetics of TCR binding were identical, implying that conformational changes at the TCR-peptide-MHC binding interface occur after an initial permissive antigen contact. These findings have implications for the rational design of vaccines targeting viruses with unstable genomes.

T cell cross-reactivity and conformational changes during TCR engagement., Lee JK, Stewart-Jones G, Dong T, Harlos K, Di Gleria K, Dorrell L, Douek DC, van der Merwe PA, Jones EY, McMichael AJ, J Exp Med. 2004 Dec 6;200(11):1455-66. PMID:15583017

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Function

[1A02_HUMAN] Involved in the presentation of foreign antigens to the immune system.

About this Structure

2v2x is a 6 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2bsv. Full crystallographic information is available from OCA.

See Also

Reference

  • Lee JK, Stewart-Jones G, Dong T, Harlos K, Di Gleria K, Dorrell L, Douek DC, van der Merwe PA, Jones EY, McMichael AJ. T cell cross-reactivity and conformational changes during TCR engagement. J Exp Med. 2004 Dec 6;200(11):1455-66. PMID:15583017 doi:10.1084/jem.20041251
Retrieved from "http://www.proteopedia.org/wiki/index.php/2v2x"
Personal tools