Structural highlights
Function
ST1C3_HUMAN Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.[1] [2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Meinl W, Donath C, Schneider H, Sommer Y, Glatt H. SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens. Food Chem Toxicol. 2008 Apr;46(4):1249-56. Epub 2007 Sep 6. PMID:17936463 doi:http://dx.doi.org/10.1016/j.fct.2007.08.040
- ↑ Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH. Structural and chemical profiling of the human cytosolic sulfotransferases. PLoS Biol. 2007 May;5(5):e97. PMID:17425406 doi:10.1371/journal.pbio.0050097
