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2qlr
From Proteopedia
| 2qlr, resolution 2.30Å () | |||||||||
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| Sites: | , , , , , , , , , and | ||||||||
| Ligands: | |||||||||
| Non-Standard Residues: | |||||||||
| Gene: | AADAT, KAT2 (Homo sapiens) | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Crystal structure of human kynurenine aminotransferase II
Human kynurenine aminotransferase II (hKAT-II) efficiently catalyzes the transamination of knunrenine to kynurenic acid (KYNA). KYNA is the only known endogenous antagonist of N-methyl-d-aspartate (NMDA) receptors and is also an antagonist of 7-nicotinic acetylcholine receptors. Abnormal concentrations of brain KYNA have been implicated in the pathogenesis and development of several neurological and psychiatric diseases in humans. Consequently, enzymes involved in the production of brain KYNA have been considered potential regulatory targets. In this article, we report a 2.16A crystal structure of hKAT-II and a 1.95A structure of its complex with kynurenine. The protein architecture of hKAT-II reveals that it belongs to the fold-type I pyridoxal 5-phosphate (PLP)-dependent enzymes. In comparison with all subclasses of fold-type I-PLP-dependent enzymes, we propose that hKAT-II represents a novel subclass in the fold-type I enzymes because of the unique folding of its first 65 N-terminal residues. This study provides a molecular basis for future effort in maintaining physiological concentrations of KYNA through molecular and biochemical regulation of hKAT-II.
Crystal Structure of Human Kynurenine Aminotransferase II., Han Q, Robinson H, Li J, J Biol Chem. 2008 Feb 8;283(6):3567-73. Epub 2007 Dec 5. PMID:18056995
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2QLR is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Han Q, Robinson H, Li J. Crystal structure of human kynurenine aminotransferase II. J Biol Chem. 2008 Feb 8;283(6):3567-73. Epub 2007 Dec 5. PMID:18056995 doi:10.1074/jbc.M708358200
Page seeded by OCA on Tue Feb 17 00:23:35 2009
