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2q8k
From Proteopedia
| 2q8k, resolution 1.60Å () | |||||||||
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| Ligands: | , | ||||||||
| Gene: | PA2G4, EBP1 (Homo sapiens) | ||||||||
| Domains: | PA2G4-like | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
The crystal structure of Ebp1
The ErbB-3 receptor binding protein (Ebp1) is a member of the proliferation-associated 2G4 (PA2G4) family implicated in regulation of cell growth and differentiation. Here, we report the crystal structure of the human Ebp1 at 1.6 A resolution. The protein has the conserved pita bread fold of methionine aminopeptidases, but without the characteristic enzymatic activity. Moreover, Ebp1 is known to interact with a number of proteins and RNAs involved in either transcription regulation or translation control. The structure provides insights in how Ebp1 discriminates between its different interaction partners.
The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions., Kowalinski E, Bange G, Bradatsch B, Hurt E, Wild K, Sinning I, FEBS Lett. 2007 Sep 18;581(23):4450-4. Epub 2007 Aug 27. PMID:17765895
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2Q8K is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kowalinski E, Bange G, Bradatsch B, Hurt E, Wild K, Sinning I. The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions. FEBS Lett. 2007 Sep 18;581(23):4450-4. Epub 2007 Aug 27. PMID:17765895 doi:10.1016/j.febslet.2007.08.024
Page seeded by OCA on Mon Feb 16 20:51:44 2009
