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|2oau, resolution 3.70Å ()|
|Gene:||mscS (Escherichia coli)|
Mechanosensitive Channel of Small Conductance (MscS)
The mechanosensitive channel of small conductance (MscS) responds both to stretching of the cell membrane and to membrane depolarization. The crystal structure at 3.9 angstroms resolution demonstrates that Escherichia coli MscS folds as a membrane-spanning heptamer with a large cytoplasmic region. Each subunit contains three transmembrane helices (TM1, -2, and -3), with the TM3 helices lining the pore, while TM1 and TM2, with membrane-embedded arginines, are likely candidates for the tension and voltage sensors. The transmembrane pore, apparently captured in an open state, connects to a large chamber, formed within the cytoplasmic region, that connects to the cytoplasm through openings that may function as molecular filters. Although MscS is likely to be structurally distinct from other ion channels, similarities in gating mechanisms suggest common structural elements.
Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel., Bass RB, Strop P, Barclay M, Rees DC, Science. 2002 Nov 22;298(5598):1582-7. PMID:12446901
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2oau is a 7 chain structure with sequence from Escherichia coli. This structure supersedes the now removed PDB entry 1mxm. The November 2008 RCSB PDB Molecule of the Month feature on Mechanosensitive Channels by David Goodsell is 10.2210/rcsb_pdb/mom_2008_11. Full crystallographic information is available from OCA.