Structural highlights
Publication Abstract from PubMed
Brugia malayi is a parasitic nematode that causes lymphatic filariasis in humans. Here the solution structure of the forkhead DNA binding domain of Brugia malayi DAF-16a, a putative ortholog of Caenorhabditis elegans DAF-16, is reported. It is believed to be the first structure of a forkhead or winged helix domain from an invertebrate. C. elegans DAF-16 is involved in the insulin/IGF-I signaling pathway and helps control metabolism, longevity, and development. Conservation of sequence and structure with human FOXO proteins suggests that B. malayi DAF-16a is a member of the FOXO family of forkhead proteins. Proteins 2014. (c) 2014 Wiley Periodicals, Inc.
The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a.,Casper SK, Schoeller SJ, Zgoba DM, Phillips AJ, Morien TJ, Chaffee GR, Sackett PC, Peterson FC, Crossgrove K, Veldkamp CT Proteins. 2014 Oct 9. doi: 10.1002/prot.24701. PMID:25297652[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Casper SK, Schoeller SJ, Zgoba DM, Phillips AJ, Morien TJ, Chaffee GR, Sackett PC, Peterson FC, Crossgrove K, Veldkamp CT. The solution structure of the forkhead box-O DNA binding domain of Brugia malayi DAF-16a. Proteins. 2014 Oct 9. doi: 10.1002/prot.24701. PMID:25297652 doi:http://dx.doi.org/10.1002/prot.24701
