2ma7

Structural highlights

Function

IKZF4_HUMAN DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems.^{[1] [2] [3]}

References

1. ↑ Perdomo J, Holmes M, Chong B, Crossley M. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. J Biol Chem. 2000 Dec 8;275(49):38347-54. PMID:10978333 doi:http://dx.doi.org/10.1074/jbc.M005457200
2. ↑ Koipally J, Georgopoulos K. A molecular dissection of the repression circuitry of Ikaros. J Biol Chem. 2002 Aug 2;277(31):27697-705. Epub 2002 May 15. PMID:12015313 doi:http://dx.doi.org/10.1074/jbc.M201694200
3. ↑ Perdomo J, Crossley M. The Ikaros family protein Eos associates with C-terminal-binding protein corepressors. Eur J Biochem. 2002 Dec;269(23):5885-92. PMID:12444977