First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.
2jxj
From Proteopedia
| 2jxj, 20 NMR models () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Gene: | JARID1A, RBBP2, RBP2 (Homo sapiens) | ||||||||
| |||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
NMR structure of the ARID domain from the histone H3K4 demethylase RBP2
The histone H3 lysine 4 demethylase RBP2 contains a DNA binding domain, the AT-rich interaction domain (ARID). We solved the structure of ARID by NMR, identified its DNA binding motif (CCGCCC) and characterized the binding contacts. Immunofluorescence and luciferase assays indicated that ARID is required for RBP2 demethylase activity in cells and that DNA recognition is essential to regulate transcription.
The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif., Tu S, Teng YC, Yuan C, Wu YT, Chan MY, Cheng AN, Lin PH, Juan LJ, Tsai MD, Nat Struct Mol Biol. 2008 Apr;15(4):419-21. Epub 2008 Feb 12. PMID:18270511
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2JXJ is a 1 chain structure of sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Tu S, Teng YC, Yuan C, Wu YT, Chan MY, Cheng AN, Lin PH, Juan LJ, Tsai MD. The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif. Nat Struct Mol Biol. 2008 Apr;15(4):419-21. Epub 2008 Feb 12. PMID:18270511 doi:10.1038/nsmb.1400
Page seeded by OCA on Tue Feb 17 10:15:51 2009
