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2jk4
From Proteopedia
| 2jk4, resolution 4.10Å () | |||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Contents |
STRUCTURE OF THE HUMAN VOLTAGE-DEPENDENT ANION CHANNEL
The voltage-dependent anion channel (VDAC), also known as mitochondrial porin, is the most abundant protein in the mitochondrial outer membrane (MOM). VDAC is the channel known to guide the metabolic flux across the MOM and plays a key role in mitochondrially induced apoptosis. Here, we present the 3D structure of human VDAC1, which was solved conjointly by NMR spectroscopy and x-ray crystallography. Human VDAC1 (hVDAC1) adopts a beta-barrel architecture composed of 19 beta-strands with an alpha-helix located horizontally midway within the pore. Bioinformatic analysis indicates that this channel architecture is common to all VDAC proteins and is adopted by the general import pore TOM40 of mammals, which is also located in the MOM.
Structure of the human voltage-dependent anion channel., Bayrhuber M, Meins T, Habeck M, Becker S, Giller K, Villinger S, Vonrhein C, Griesinger C, Zweckstetter M, Zeth K, Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15370-5. Epub 2008 Oct 1. PMID:18832158
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2jk4 is a 1 chain structure of Ion channels (Part II) and Porin with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Bayrhuber M, Meins T, Habeck M, Becker S, Giller K, Villinger S, Vonrhein C, Griesinger C, Zweckstetter M, Zeth K. Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15370-5. Epub 2008 Oct 1. PMID:18832158
Categories: Homo sapiens | Bayrhuber, M. | Becker, S. | Giller, K. | Griesinger, C. | Habeck, M. | Meins, T. | Villinger, S. | Vonrhein, C. | Zeth, K. | Zweckstetter, M. | Acetylation | Apoptosis | Cell membrane | Host-virus interaction | Ion transport | Membrane | Membrane protein | Mitochondrial outer membrane | Mitochondrion | Mitochondrion outer membrane | Phosphoprotein | Porin | Transmembrane | Transport | Vdac
