First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.

2jbl

From Proteopedia

Jump to: navigation, search


2jbl, resolution 2.40Å ()
Sites: , , , , , , , , , , , , , , , , , , , , , , and
Ligands: , , , , , , , ,
Non-Standard Residues:
Related: 1dxr, 1prc, 1r2c, 1vrn, 2prc, 3prc, 5prc, 6prc, 7prc
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Contents

PHOTOSYNTHETIC REACTION CENTER FROM BLASTOCHLORIS VIRIDIS

Publication Abstract from PubMed

We describe in detail the conformations of the inhibitor stigmatellin in its free form and bound to the ubiquinone-reducing (Q(B)) site of the reaction center and to the ubiquinol-oxidizing (Q(o)) site of the cytochrome bc(1) complex. We present here the first structures of a stereochemically correct stigmatellin in complexes with a bacterial reaction center and the yeast cytochrome bc1 complex. The conformations of the inhibitor bound to the two enzymes are not the same. We focus on the orientations of the stigmatellin side-chain relative to the chromone head group, and on the interaction of the stigmatellin side-chain with these membrane protein complexes. The different conformations of stigmatellin found illustrate the structural variability of the Q sites, which are affected by the same inhibitor. The free rotation about the chi1 dihedral angle is an essential factor for allowing stigmatellin to bind in both the reaction center and the cytochrome bc1 pocket.

A comparison of stigmatellin conformations, free and bound to the photosynthetic reaction center and the cytochrome bc1 complex., Lancaster CR, Hunte C, Kelley J 3rd, Trumpower BL, Ditchfield R, J Mol Biol. 2007 Apr 20;368(1):197-208. Epub 2007 Feb 11. PMID:17337272

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

2jbl is a 4 chain structure of Cytochrome c with sequence from Blastochloris viridis. This structure supersedes the now removed PDB entry 4prc. The September 2011 RCSB PDB Molecule of the Month feature on O-GlcNAc Transferase by David Goodsell is 10.2210/rcsb_pdb/mom_2011_9. Full crystallographic information is available from OCA.

See Also

Reference

  • Lancaster CR, Hunte C, Kelley J 3rd, Trumpower BL, Ditchfield R. A comparison of stigmatellin conformations, free and bound to the photosynthetic reaction center and the cytochrome bc1 complex. J Mol Biol. 2007 Apr 20;368(1):197-208. Epub 2007 Feb 11. PMID:17337272 doi:10.1016/j.jmb.2007.02.013
  • Lancaster CR, Bibikova MV, Sabatino P, Oesterhelt D, Michel H. Structural basis of the drastically increased initial electron transfer rate in the reaction center from a Rhodopseudomonas viridis mutant described at 2.00-A resolution. J Biol Chem. 2000 Dec 15;275(50):39364-8. PMID:11005826 doi:10.1074/jbc.M008225200
  • Lancaster CR, Michel H. Refined crystal structures of reaction centres from Rhodopseudomonas viridis in complexes with the herbicide atrazine and two chiral atrazine derivatives also lead to a new model of the bound carotenoid. J Mol Biol. 1999 Feb 26;286(3):883-98. PMID:10024457 doi:10.1006/jmbi.1998.2532
  • Lancaster CR, Michel H. The coupling of light-induced electron transfer and proton uptake as derived from crystal structures of reaction centres from Rhodopseudomonas viridis modified at the binding site of the secondary quinone, QB. Structure. 1997 Oct 15;5(10):1339-59. PMID:9351808
  • Deisenhofer J, Epp O, Sinning I, Michel H. Crystallographic refinement at 2.3 A resolution and refined model of the photosynthetic reaction centre from Rhodopseudomonas viridis. J Mol Biol. 1995 Feb 24;246(3):429-57. PMID:7877166 doi:10.1006/jmbi.1994.0097
  • Deisenhofer J, Michel H. The Photosynthetic Reaction Center from the Purple Bacterium Rhodopseudomonas viridis. Science. 1989 Sep 29;245(4925):1463-73. PMID:17776797 doi:10.1126/science.245.4925.1463
  • Deisenhofer J, Epp O, Miki K, Huber R, Michel H. X-ray structure analysis of a membrane protein complex. Electron density map at 3 A resolution and a model of the chromophores of the photosynthetic reaction center from Rhodopseudomonas viridis. J Mol Biol. 1984 Dec 5;180(2):385-98. PMID:6392571
  • Michel H. Three-dimensional crystals of a membrane protein complex. The photosynthetic reaction centre from Rhodopseudomonas viridis. J Mol Biol. 1982 Jul 5;158(3):567-72. PMID:7131557

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://www.proteopedia.org/wiki/index.php/2jbl"
Personal tools