2j16

Structural highlights

Function

SDP1_YEAST Mediates dephosphorylation of MAPK substrates such as SLT2, acquiring enhanced catalytic activity under oxidative conditions.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Tyrosine phosphatase 3D structures

References

1. ↑ Collister M, Didmon MP, MacIsaac F, Stark MJ, MacDonald NQ, Keyse SM. YIL113w encodes a functional dual-specificity protein phosphatase which specifically interacts with and inactivates the Slt2/Mpk1p MAP kinase in S. cerevisiae. FEBS Lett. 2002 Sep 11;527(1-3):186-92. PMID:12220658
2. ↑ Fox GC, Shafiq M, Briggs DC, Knowles PP, Collister M, Didmon MJ, Makrantoni V, Dickinson RJ, Hanrahan S, Totty N, Stark MJ, Keyse SM, McDonald NQ. Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases. Nature. 2007 May 24;447(7143):487-92. Epub 2007 May 9. PMID:17495930 doi:http://dx.doi.org/10.1038/nature05804