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2hr9
From Proteopedia
| 2hr9, 20 NMR models () | |||||||||
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| Gene: | TPT1 (Homo sapiens) | ||||||||
| Domains: | TCTP | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Solution structure of human translationally controlled tumor protein
Human translationally controlled tumor protein (TCTP) is a growth-related, calcium-binding protein. We determined the solution structure and backbone dynamics of human TCTP, and identified the calcium-binding site of human TCTP using multi-dimensional NMR spectroscopy. The overall structure of human TCTP has a rather rigid well-folded core and a very flexible long loop connected by a short two-strand beta-sheet, which shows a conserved fold in the TCTP family. The C-terminal portions of loop L(alpha3beta8) and strand beta9 and the N-terminal region of strand beta8 may form a calcium-binding site in the human TCTP structure, which is largely conserved in the sequence alignment of TCTPs. The K(d) value for the calcium binding is 0.022-0.025 M indicating a very weak calcium-binding site.
Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR., Feng Y, Liu D, Yao H, Wang J, Arch Biochem Biophys. 2007 Nov 1;467(1):48-57. Epub 2007 Aug 30. PMID:17897616
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2HR9 is a 1 chain structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1y41. Full experimental information is available from OCA.
Reference
- Feng Y, Liu D, Yao H, Wang J. Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR. Arch Biochem Biophys. 2007 Nov 1;467(1):48-57. Epub 2007 Aug 30. PMID:17897616 doi:10.1016/j.abb.2007.08.021
Page seeded by OCA on Tue Feb 17 14:25:19 2009
