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2hdc

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2hdc, 20 NMR models ()
Gene: GENESIS (Rattus norvegicus)
Domains: FH
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF TRANSCRIPTION FACTOR GENESIS/DNA COMPLEX

Publication Abstract from PubMed

Genesis is an HNF-3/fkh homologous protein. By using multi-dimensional NMR techniques, we have obtained the solution structure and backbone dynamics of Genesis complexed with a 17 base-pair DNA. Our results indicate that both the local folding and dynamic properties of Genesis are perturbed when it binds to the DNA site. Our data show that a conserved flexible amino acid sequence (wing 1) makes dynamic contacts to DNA in the complex and a short helix is induced by Genesis-DNA interactions. Our data indicate that, unlike the HNF-3gamma/DNA complex, a magnesium ion is not required in forming the stable Genesis-DNA complex.

Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex., Jin C, Marsden I, Chen X, Liao X, J Mol Biol. 1999 Jun 18;289(4):683-90. PMID:10369754

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

2HDC is a 3 chains structure of sequences from Rattus norvegicus. Full experimental information is available from OCA.

Reference

  • Jin C, Marsden I, Chen X, Liao X. Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex. J Mol Biol. 1999 Jun 18;289(4):683-90. PMID:10369754 doi:10.1006/jmbi.1999.2819

Page seeded by OCA on Wed Feb 18 06:33:10 2009

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