First time at Proteopedia? Click on the green links: they change the 3D image. Click and drag the molecules. Proteopedia is a 3D, interactive encyclopedia of proteins, RNA, DNA and other molecules. With a free user account, you can edit pages in Proteopedia. Visit the Main Page to learn more.
2hck
From Proteopedia
| 2hck, resolution 3.00Å () | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Sites: | , , and | ||||||||
| Ligands: | , | ||||||||
| Non-Standard Residues: | |||||||||
| Gene: | HUMAN HCK (Homo sapiens) | ||||||||
| Activity: | Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 | ||||||||
| |||||||||
| |||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
SRC FAMILY KINASE HCK-QUERCETIN COMPLEX
The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.
Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:9024658
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2HCK is a 2 chains structure with sequences from Homo sapiens. The July 2003 RCSB PDB Molecule of the Month feature on Src Tyrosine Kinase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2003_7. Full crystallographic information is available from OCA.
Reference
- Sicheri F, Moarefi I, Kuriyan J. Crystal structure of the Src family tyrosine kinase Hck. Nature. 1997 Feb 13;385(6617):602-9. PMID:9024658 doi:10.1038/385602a0
Page seeded by OCA on Thu Jan 21 09:47:30 2010
