2h2n
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proteopedia linkproteopedia linkCrystal structure of human soluble calcium-activated nucleotidase (SCAN) with calcium ion
Structural highlights
DiseaseCANT1_HUMAN Desbuquois syndrome. The disease is caused by mutations affecting the gene represented in this entry. FunctionCANT1_HUMAN Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.[1] [2] [3] Evolutionary ConservationCheck, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References
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Categories: Homo sapiens | Large Structures | Herr AB | Horii K | Kirley TL | Yang M