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2h2k
From Proteopedia
| 2h2k, resolution 2.00Å () | |||||||||||
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| Domains: | S-100A13 | ||||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||
Crystal Structure Analysis of Human S100A13
The S100 protein family is the largest group of calcium-binding protein families, which consists of at least 25 members. S100A13, which is widely expressed in a variety of tissues, is a unique member of the S100 protein family. Previous reports showed that S100A13 might be involved in the stress-induced release of some signal peptide-less proteins (such as FGF-1 and IL-1alpha) and also associated with inflammatory functions. It was also reported that S100A13 is a new angiogenesis marker. Here we report the crystal structure of the Ca(2+)-bound form of S100A13 at 2.0 A resolution. S100A13 is a homodimer with four EF-hand motifs in an asymmetric unit, displaying a folding pattern similar to other S100 members. However, S100A13 has the unique structural feature with all alpha-helices being amphiphilic, which was not found in other members of S100s. We propose that this characteristic structure of S100A13 might be related to its ability to mediate the release of FGF-1 and IL-1alpha.
Crystal structure study on human S100A13 at 2.0 A resolution., Li M, Zhang PF, Pan XW, Chang WR, Biochem Biophys Res Commun. 2007 May 11;356(3):616-21. Epub 2007 Mar 12. PMID:17374362
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
2H2K is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Li M, Zhang PF, Pan XW, Chang WR. Crystal structure study on human S100A13 at 2.0 A resolution. Biochem Biophys Res Commun. 2007 May 11;356(3):616-21. Epub 2007 Mar 12. PMID:17374362 doi:10.1016/j.bbrc.2007.03.014
Page seeded by OCA on Mon Feb 16 13:10:26 2009
