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2gsq

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2gsq, resolution 2.20Å ()
Ligands: ,
Gene: CDNA INSERT OF CLONE PGST5 (Nototodarus sloanii)
Activity: Glutathione transferase, with EC number 2.5.1.18
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Contents

GLUTATHIONE S-TRANSFERASE FROM SQUID DIGESTIVE GLAND COMPLEXED WITH S-(3-IODOBENZYL)GLUTATHIONE

Publication Abstract from PubMed

The crystal structure of the sigma class glutathione transferase from squid digestive gland in complex with S-(3-iodobenzyl)glutathione reveals a third binding site for the glutathione conjugate besides the two in the active sites of the dimer. The additional binding site is near the crystallographic two-fold axis between the two alpha 4-turn-alpha 5 motifs. The principal binding interactions with the conjugate include specific electrostatic interactions between the peptide and the two subunits and a hydrophobic cavity found across the two-fold axis that accommodates the 3-iodobenzyl group. Thus, two identical, symmetry-related but mutually exclusive binding modes for the third conjugate are observed. The hydrophobic pocket is about 14 A from the hydroxyl group of Tyr-7 in the active site. This site is a potential transport binding site for hydrophobic molecules or their glutathione conjugates.

Location of a potential transport binding site in a sigma class glutathione transferase by x-ray crystallography., Ji X, von Rosenvinge EC, Johnson WW, Armstrong RN, Gilliland GL, Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8208-13. PMID:8710848

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure

2gsq is a 1 chain structure with sequence from Nototodarus sloanii. Full crystallographic information is available from OCA.

See Also

Reference

  • Ji X, von Rosenvinge EC, Johnson WW, Armstrong RN, Gilliland GL. Location of a potential transport binding site in a sigma class glutathione transferase by x-ray crystallography. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8208-13. PMID:8710848

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